Common Prescriptions Linked to Increased Dementia Risk
Many prescriptions have been linked to memory loss! We hope to answer these questions and more below. So, if you or a loved one is worried about or currently living with this problem, please keep reading…
How Common Is Alzheimer’s Disease?
Most people associate Alzheimer’s with memory loss, one of first and most common symptoms of the disease. On average, the progressive (and currently) irreversible brain disorder starts affecting people after 60 years of age.  However, there are many factors that contribute to an individual’s experience such as their genes, diet, lifestyle habits, and more.
10 Early Warning Signs and Symptoms of Alzheimer’s
- Memory loss
- Inability to plan things or solve problems
- Difficulty completing simple tasks
- Getting confused about times, dates, and places
- Inability to understand spatial relationships and visuals
- New problems when it comes to speaking or writing
- Forgetting where you put stuff and being unable to retrace steps
- Increasingly poor judgement
- Growing less and less social
- Uncharacteristic changes in mood and personality
How About Dementia?
Not unlike Alzheimer’s disease, the most common form of dementia, general dementia is also a progressive syndrome that impairs your cognitive function. That is, your ability to think, reason, remember, and behave properly (if at all). Many of the symptoms actually overlap with those of Alzheimer’s disease. 
Growing by 10 million new cases per year, there are around 50 million people worldwide currently living with dementia… According to the World Health Organization, that’s a figure that we expect to hit 82,000,000 by 2030 and 152,000,000. 
Although these numbers are alarming, there are numerous ways to decrease your risk of development Alzheimer’s disease or other forms of dementia – naturally and otherwise. But the possibility of keeping the number of dementia cases to a minimum seems unlikely when so many people are on medications that can increase the likelihood of getting it.
Common Drugs Like Benadryl Linked to Increased Dementia Risk
In March 2015, researchers published a prospective cohort study in JAMA Internal Medicine called “Cumulative Use of Strong Anticholinergics and Incident Dementia.” The University of Washington and Seattle healthcare system, Group Health, conducted the long-term study which tracked 3,434 men and women who were aged 65 and up, and had no dementia when the study began. 
The team accessed every participant’s history of drug use for the previous decade, including both over-the-counter and prescription drugs. Over a 7-year timeline, they followed up with all the participants every two years, during which 797 participants developed dementia (637 of whom developed Alzheimer’s disease).
As researchers looked back on what those 797 individuals took, anticholinergic drugsbecame the main suspect. The most common anticholinergics participants used were tricyclic antidepressants, first-generation antihistamines, and bladder antimuscarinics. Compared to those who didn’t take anticholinergic drugs, people who did for as little as three years were 54% more likely to develop dementia.
What Are Anticholinergics?
Usually, these types of drugs are prescribed to treat problems including urinary incontinence, Parkinson’s disease, and chronic obstructive pulmonary disorder (COPD). Anticholinergic drugs’ main purpose is to block the actions and effects of acetylcholine, a neurotransmitter which causes muscles to contract, activates pain responses and regulates endocrine and REM sleep functions. 
It’s just a natural fact of life – as we age, our bodies’ ability to produce acetylcholine decreases.  Since the brain actually contains many acetylcholine-producing cells, as Harvard editor Beverly Merz highlights, “blocking its effects can deliver a double whammy to older people.” 
If you want to keep your head clear and brain functioning as highly as possible, steering clear of anticholinergic drugs seems ideal. However, it is important to recognize that the long-term study revealed only a small portion of drugs was interfering with cognitive function. So, please discuss with your doctor if you’re thinking of getting off any prescribed medications.
Experiencing Memory Loss? It’s Not Necessarily Alzheimer’s
There are reversible dementias that, although worrisome, people can treat and even overcome. Some of these problems might surprise you: 
Although this condition seems similar to dementia, the mental changes that occur in delirium happen within days in comparison to months or years. Another key distinction between these two problems is that with dementia, you maintain consciousness; with delirium, you don’t.
People with depression have likely experienced moments of forgetfulness and disorientation. A simple way to tell the difference between depression and dementia is looking at the timeline. Depressed people become depressed first and experience memory-related symptoms later, whereas people with dementia become depressed as a result of their declining cognitive function.
3) Vitamin B12 Deficiency
This crucial deficiency can lead to pernicious anemia, a rare condition associated with confusion, slowness, apathy, and irritability.
Individuals with hypothyroidism will likely exhibit dementia-like symptoms.
People who are alcoholics can suffer bouts of confusion and amnesia which can mimic the same experiences as someone with Alzheimer’s disease. Although alcoholism can deteriorate the ability to remember and orientate oneself, abstinence and overcoming addiction can help reverse side effects.
 Alzheimer’s Statistics. (n.d.). Retrieved from https://www.alzheimers.net/resources/alzheimers-statistics/
 10 Early Signs and Symptoms of Alzheimer’s. (n.d.). Retrieved from https://www.alz.org/alzheimers-dementia/10_signs
 Dementia. (n.d.). Retrieved from http://www.who.int/news-room/fact-sheets/detail/dementia
 Gray, S. L. (2015, March 01). Strong Anticholinergics and Incident Dementia. Retrieved from https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2091745
 Anticholinergics: List, Side Effects, and More. (n.d.). Retrieved from https://www.healthline.com/health/anticholinergics
 Acetylcholine (ACh). (n.d.). Retrieved from http://memorylossonline.com/glossary/acetylcholine.html
 Merz, B. (2017, May 23). Common anticholinergic drugs like Benadryl linked to increased dementia risk. Retrieved from https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667
 What’s Causing Your Memory Loss? (n.d.). Retrieved from https://www.helpguide.org/harvard/whats-causing-your-memory-loss.htm#top
 Alzheimer’s Disease Fact Sheet. (n.d.). Retrieved from https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet
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